Joanna is in a touring girl's choir and Mark is a struggling architect. when they first meet on the road in Europe. The film follows their life together --- through courtship and marriage, infidelity and parenthood --- all on the road in a variety of cars through a score of time-shifting vignettes.

Louise is working in a diner as a waitress and has some problems with her boyfriend Jimmy, who, as a musician, is always on the road. Thelma is married to Darryl who likes his wife to stay quiet in the kitchen so that he can watch football on TV. One day they decide to break out of their normal life and jump in the car and hit the road. Their journey, however, turns into a flight when Louise kills a man who threatens to rape Thelma. They decide to go to Mexico, but soon they are hunted by...

Big-hearted Chicago family man Chet has brought his family to a lakeside resort area, and although his wife and kids aren't quite as excited as he is, Chet has high hopes for the vacation. However, his optimism is sabotaged when his obnoxious brother-in-law Roman drops in unexpectedly, along with his snooty, strange family. Chet and his family try to stay open-minded, but they find it difficult to relax and enjoy themselves because of the constant annoyance of Roman's presence.

Searching for family. In the early twenty-first century, zombies have taken over America. A shy and inexperienced college student in Texas has survived by following his 30 rules: such as "look in the back seat," "double-tap," "avoid public restrooms." He decides to travel to Ohio to see if his parents are alive. He gets a ride with a boisterous zombie-hating good-old boy headed for Florida, and soon they confront a young woman whose sister has been bitten by a zombie and wants to be put out of...

Bounty hunter Jack Walsh is sent to find and return bail jumper and former Mafia accountant, Jonathan "The Duke" Mardukas. The FBI have had no success it locating The Duke, so when Jack finds him in next to no time, they are a little embarrassed. In order to collect his $100,000 fee, Jack must take The Duke from New York to Los Angeles. However, the Mafia and the FBI have other ideas, as does Marvin, a rival bounty hunter. On their long cross-country trip to LA, the two get to know each other...

Ryan Bingham is a corporate downsizing expert whose cherished life on the road is threatened just as he is on the cusp of reaching ten million frequent flyer miles and just after he's met the frequent-traveler woman of his dreams.

In LA, Jason Lair is recently separated, living with his grandfather and his son; he's a banker, tense, with a limp. Grandfather Henry, an archaeologist, wants to take the family van on a trip to Albuquerque. His plans are interrupted when Turner, Jason's father and Henry's son, appears after years of absence. Henry wants to celebrate family, as does Zach, Jason's son; Jason is angry and distant, Turner seems detached and says he's got a bus to catch in the morning. This prompts Henry to put in...